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Shisheng Wang Selected Research

Oleanolic Acid

11/2020miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis.
1/2018Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
12/2017Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
11/2016Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
2/2016Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
1/2016SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
12/2015SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.

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Shisheng Wang Research Topics

Disease

14Neoplasms (Cancer)
10/2022 - 02/2016
4Breast Neoplasms (Breast Cancer)
01/2022 - 12/2015
4Hypoxia (Hypoxemia)
11/2021 - 01/2019
4Pancreatic Neoplasms (Pancreatic Cancer)
10/2021 - 01/2018
3Lung Neoplasms (Lung Cancer)
01/2022 - 11/2016
2Neoplasm Metastasis (Metastasis)
10/2022 - 10/2021
2Fibrosis (Cirrhosis)
06/2022 - 01/2021
2Carcinoma (Carcinomatosis)
01/2022 - 08/2020
2Mitochondrial Diseases (Mitochondrial Disease)
01/2021 - 11/2020
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 12/2017
1Cardiovascular Diseases (Cardiovascular Disease)
07/2022
1Myocardial Infarction
07/2022
1Fatty Liver
06/2022
1Brain Infarction
01/2022
1Ischemic Stroke
01/2022
1Brain Injuries (Brain Injury)
01/2022
1Neurofibromatosis 1 (Neurofibromatosis Type I)
01/2022
1Pancreatitis
05/2021
1Infections
01/2021
1Colorectal Neoplasms (Colorectal Cancer)
01/2021
1Immune System Diseases (Immune Disorders)
08/2020
1Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
08/2020
1Thyroiditis
01/2020
1Phototoxic Dermatitis (Phototoxicity)
10/2017
1Inflammation (Inflammations)
11/2016
1Stomach Neoplasms (Stomach Cancer)
02/2016
1Venous Thrombosis (Deep-Vein Thrombosis)
05/2012
1Headache (Headaches)
05/2012
1Aphasia (Dysphasia)
05/2012
1Dysentery
05/2012
1Stroke (Strokes)
05/2012

Drug/Important Bio-Agent (IBA)

7Oleanolic AcidIBA
11/2020 - 12/2015
4Pharmaceutical PreparationsIBA
01/2022 - 05/2012
4Proteins (Proteins, Gene)FDA Link
11/2021 - 02/2016
3Biological ProductsIBA
11/2021 - 04/2019
3Antineoplastic Agents (Antineoplastics)IBA
11/2021 - 12/2015
32- morpholinomethyl- 3- oxoolean- 12- en- 28- oic acidIBA
01/2018 - 01/2016
3SZC017IBA
12/2017 - 12/2015
2ProteomeIBA
06/2022 - 10/2020
2Glycoproteins (Glycoprotein)IBA
06/2022 - 01/2020
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2021 - 10/2021
2Photosensitizing Agents (Photosensitizers)IBA
11/2021 - 01/2021
21-phenyl-3,3-dimethyltriazene (PDT)IBA
11/2021 - 01/2021
2Kazal Pancreatic Trypsin InhibitorIBA
10/2021 - 11/2020
2K73-03IBA
10/2021 - 11/2020
2GlycopeptidesIBA
08/2020 - 01/2020
2Biomarkers (Surrogate Marker)IBA
08/2020 - 01/2020
1AflatoxinsIBA
10/2022
1IntegrinsIBA
10/2022
1shexiang baoxinIBA
07/2022
1Glucose (Dextrose)FDA LinkGeneric
06/2022
1C-Reactive ProteinIBA
06/2022
1Ceruloplasmin (Ferroxidase)IBA
06/2022
1Triglycerides (Triacylglycerol)IBA
06/2022
1Myristoylated Alanine-Rich C Kinase SubstrateIBA
01/2022
1pevonedistatIBA
01/2022
1rottlerinIBA
01/2022
14- (4- dihexadecylaminostyryl)- N- methylpyridium (DiA)IBA
01/2022
1Enzyme Inhibitors (Inhibitors, Enzyme)IBA
01/2022
1bis(p-chlorophenyl)acetic acid (DDA)IBA
01/2022
1Protein Kinase CIBA
01/2022
1Myosin Light Chains (Myosin Essential Light Chain)IBA
01/2022
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2022
1Cullin Proteins (Cullins)IBA
01/2022
1Therapeutic UsesIBA
11/2021
1Messenger RNA (mRNA)IBA
11/2021
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2021
1Oxygen (Dioxygen)IBA
11/2021
1Indicators and Reagents (Reagents)IBA
10/2021
1Epidermal Growth Factor (EGF)IBA
10/2021
1GemcitabineFDA Link
10/2021
1Amino AcidsFDA Link
09/2021
1taurolithocholic acid 3-sulfate (TLC-S)IBA
05/2021
1InterleukinsIBA
01/2021
1ErbB Receptors (EGF Receptor)IBA
01/2021
1Polysaccharides (Glycans)IBA
01/2021
1Cisplatin (Platino)FDA LinkGeneric
01/2021
1VaccinesIBA
01/2021
1CytokinesIBA
01/2021
1Death Domain ReceptorsIBA
01/2021
1InflammasomesIBA
01/2021
1Immunoglobulins (Immunoglobulin)IBA
08/2020
1(R,S)- 4- ((4'- methoxy- 4- (methyl)- 3- ((4- methoxyphenyl)ethynyl)biphenyl- 2- yl)(4- methoxyphenyl)methylene)- 2,5- cyclohexadien- 1- one,IBA
01/2020
1LuciferasesIBA
04/2019
1Alkynes (Acetylenes)IBA
04/2019
1neolamellarin AIBA
01/2019
1PyrrolesIBA
01/2019
1AlkaloidsIBA
01/2019
1Transcription Factors (Transcription Factor)IBA
01/2018
1phytochlorinIBA
10/2017
1ArtesunateIBA
10/2017
1Type I DNA Topoisomerases (Topoisomerase I)IBA
02/2016
1Acetylcysteine (Siran)FDA LinkGeneric
12/2015
1Caspase 3 (Caspase-3)IBA
12/2015
1Adenosine Diphosphate (ADP)IBA
05/2012
1ThrombinFDA Link
05/2012
1CollagenIBA
05/2012

Therapy/Procedure

6Therapeutics
10/2022 - 12/2017
2Photochemotherapy (Photodynamic Therapy)
11/2021 - 01/2021
1Drug Therapy (Chemotherapy)
01/2018